• iHuman team and collaborators unveiled the Z-genome Biosynthetic Pathway
    Recently, Dr. Zhao Suwen’s team at the iHuman Institute, collaborating with other scientists from Tianjin University, and the Agency for Science, Technology and Research (A*STAR)/ University of Illinois at Urbana-Champaign (UIUC) have solved a long-standing mystery of Z genome that comprises entirely non-canonical Z-T base pairs instead of canonical A-T base pairs in bacteriophages (Figure 1). Th...
    2021-05-02
  • iHuman Distinguished Professor Kurt Hermann Wüthrich Honored with the 2020 Magnolia Award
    iHuman Institute Distinguished Professor Dr. Kurt Hermann Wüthrich, Nobel  Laureate in Chemistry, was honored with the 2020 Magnolia Award in recognition of his great contributions and achievements in scientific research, and for nurturing and mentoring Chinese young scientists.The Magnolia Award, which has been awarded annually since 1989, was established to commend...
    2020-09-21
  • The iHuman Team Makes Breakthrough in Anticancer Drug Discovery
    A research team from iHuman Institute of ShanghaiTech University has made a new discovery in the field of human chemokine system. This study fills in a critical gap, which is how endogenous chemokines activate endogenous chemokine receptors. The article, entitled Structure basis of CXC chemokine receptor 2 activation and signaling was published in the prestigious journal Nature, available onl...
    2020-07-02
  • iHuman Institute Publishes Breakthrough in Hunt for Obesity Drug Treatment
    Researchers at the iHuman Institute of ShanghaiTech University have made another discovery in the advancement of human health, this time involving an important protein for controlling obesity - the melanocortin-4 receptor. The research is to be published in the prestigious journal Science, available online from April 24, 2020. The Stevens lab which led the work has been intensely focused...
    2020-04-24
  • Top Diabetes Drug Target Structure Published by International Collaboration Led by iHuman Institute, ShanghaiTech University
    Researchers from the iHuman Institute at ShanghaiTech University, Chinese Academy of Sciences (Shanghai Institute of Materia Medica, SIMM), East China Normal University, University of Southern California, and the Danish biopharmaceutical company, Novo Nordisk, have determined the first “peptide-free inactive structure of the full-length human glucagon like peptide-1 receptor (GLP-1R) at atomic re...
    2020-03-10
  • Discovery of Novel GPCR Modulators Through Affinity Mass Spectrometry-Based Screening of Herbal Extracts
    Recently, Prof. Shui Wenqing’s group from iHuman Institute and SLST has made a breakthrough in bioactive screening from herbal extracts. Based on their previous work in developing the affinity mass spectrometry (MS) technique for ligand screening (Chemical Science 2018, Analytical Chemistry 2019), they combined affinity MS-based screening with compound isolation and ...
    2020-03-03
  • 3D Protein Structures Help the Orphan Receptor Find Its Way Home: Scientists Uncovered the 3D Structures of an Orphan GPCR and Published Their Results in Nature
    Recently, scientists from Xu Fei's lab at iHuman Institute, ShanghaiTech University with their collaborators made a new breakthrough in the field of human cell signaling research. They successfully resolved the 3D protein structures of the first human orphan GPR52 receptor and presented a full structural landscape covering the receptor’s different functional states: ligand-free state, ligand-...
    2020-02-20
  • ShanghaiTech Scientists Decipher the Structures of Signaling Forms of Human “Marijuana Receptors”
    A team of scientists led by Professors Liu Zhi-Jie and Hua Tian at the iHuman Institute of ShanghaiTech University has determined and analyzed the high-resolution atomic structures of human cannabinoid receptors, also known as the “marijuana receptors”, 1 and 2 (CB1 and CB2) complexed with their agonists and downstream signaling G proteins. The results, described in a paper entitl...
    2020-01-31
  • Research Uncovers First Active Δ-opioid Receptor Structures
    Science Advances
    iHuman Institute Professor Raymond C. Stevens and his team recently elucidated the first crystal structures of the δ-opioid receptor (DOP) in an activated state. The results were published in the journal Science Advances, in an article titled “Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.” ShanghaiTech University PhD student Yu Jing from R...
    2019-12-20
  • Structural Biologists Attend Macromolecular Crystallography Workshop
    From Oct 12th to Oct 21th, the CCP4/Shanghai School in Macromolecular Crystallography: From Data Collection to Structure Refinement and Beyond was held at National Facility for Protein Science Shanghai (NFPS) and ShanghaiTech University. Jointly organized by Collaborative Computational Project No. 4 Software for Macromolecule X-Ray Crystallography (CCP4), NFPS, iHuman Institute of ShanghaiTech and...
    2019-10-31
  • ShanghaiTech Hosts BSR13 Conference
    On September 24, the 13th International Conferenceon Biology and Synchrotron Radiation successfully concluded at ShanghaiTech University. Jointly organized by iHuman Institute, Institute of High Energy Physics of the Chinese Academy of Science, Shanghai Synchrotron Radiation Facility, Biophysical Society of China, Chinese Crystallographic Society and Shanghai Society of Biophysics, it was co-...
    2019-10-23
  • Shanghai Honors iHuman Founding Director
    iHuman Institute Founding Director Dr. Raymond C. Stevens received the 2019 Magnolia Golden Award in recognition of his great contributions to scientific research achievement and for nurturing and mentoring Chinese young scientists.The Magnolia Golden Award has been awarded annually since 1993, and was established to recognize foreign experts and partners for their outstanding contributions to Sha...
    2019-10-10
  • iHuman Researcher Wins Young Scientist Award
    iHuman Research Assistant Professor Dr. Chen Ming was awarded the 2019 Yangtze River Delta Neuroscience Young Scientist Award on August 15, 2019. Jointly established by Shanghai Society of Neuroscience, Anhui Society for Neuroscience, Zhejiang Society for Neuroscience and Jiangsu Society for Neuroscience, the award is given each year to six young scientists in the research field of neuroscience fo...
    2019-10-09
  • Novel AAV Vector May Lead to Improved Cochlear Therapy
    Nature Communications
    On August 19th, an article by a research group led by iHuman Institute and SLST Assistant Professor Zhong Guisheng, working with collaborators Southeast University Professor Chai Renjie and Fudan University Professor Li Huawei was published in Nature Communication, entitled ‘AAV-ie enables safe and efficient gene transfer to inner ear cells.’ They have identified a novel adeno-associated virus (A...
    2019-10-09